Human Collagen Type IV Alpha 3 (COL4A3) Protein

Este producto es parte de COL4A3 - Collagen Type IV Alpha 3 Chain
Human Collagen Type IV Alpha 3 (COL4A3) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein COL4A3

proveedor

Abbexa

reference

abx168068

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human COL4A3 Protein is a recombinant Human protein expressed in E. coli.


Background

COL4A3 is one of the six α-chains that compose type IV collagen, a major structural component of basement membranes. COL4A3 assembles into a triple-helical network with COL4A4 and COL4A5 to provide mechanical support, structural stability, and selective permeability in tissues such as the kidney glomerulus, lung alveoli, and the ocular lens. Mutations in COL4A3 are associated with Alport syndrome, a hereditary disorder characterized by progressive kidney disease, sensorineural hearing loss, and ocular abnormalities caused by defective basement membranes. It also plays a role in tissue repair and angiogenesis by interacting with signaling molecules such as integrins and matrix metalloproteinases (MMPs). Dysregulated COL4A3 expression contributes to fibrosis and tumor metastasis by influencing extracellular matrix (ECM) remodeling. Knockout models show abnormal glomerular basement membranes, hematuria, and progressive renal failure, highlighting COL4A3's critical role in basement membrane assembly, tissue integrity, and kidney function.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Collagen Type IV Alpha 3 (COL4A3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 30.5 kDa Observed MW (SDS-PAGE): 30 kDa Concentration: Prior to lyophilization: 500 µg/ml Sequence Fragment: Leu1428-His1670 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

COL4A3


dry ice

No


availability

Shipped within 5-7 working days.


alias

ATS2,ATS3,BFH2,ATS3A,ATS3B,Goodpasture antigen


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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