Human Cluster Of Differentiation 14 (CD14) CLIA Kit
845€ (96 tests)
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name
Human Cluster Of Differentiation 14 (CD14) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx491882
tested applications
CLIA
Description
Human Cluster Of Differentiation 14 (CD14) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Cluster Of Differentiation 14 (CD14) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 3.75 ng/ml - 60 ng/ml |
| Sensitivity | < 1.52 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Cluster Of Differentiation 14,CD14,Myeloid Cell-Specific Leucine-Rich Glycoprotein,Monocyte differentiation antigen CD14 |
| Background | CLIA Kits CD14 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CD14 is a pattern recognition receptor (PRR) expressed on the surface of monocytes, macrophages, and neutrophils, where it plays a key role in the innate immune response CD14 functions as a co-receptor for the detection of lipopolysaccharides (LPS) derived from the outer membrane of Gram-negative bacteria It forms a complex with LPS-binding protein (LBP) and transduces signals via the Toll-like receptor 4 (TLR4)-MD2 complex, initiating downstream activation of nuclear factor kappa B (NF-κB) and subsequent production of pro-inflammatory cytokines CD14 exists in two forms, a membrane-bound form (mCD14) and a soluble form (sCD14), both of which contribute to LPS recognition and systemic inflammatory responses Dysregulation of CD14 signaling has been implicated in sepsis, chronic inflammatory diseases, and autoimmune disorders Elevated levels of soluble CD14 serve as a biomarker for monocyte activation in conditions such as HIV, cardiovascular disease, and metabolic disorders
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