Human Cleavage stimulation factor subunit 2 (CSTF2) ELISA Kit
715€ (96 tests)
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name
Human Cleavage stimulation factor subunit 2 (CSTF2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx508951
tested applications
ELISA
Description
Human Cleavage stimulation factor subunit 2 (CSTF2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Cleavage stimulation factor subunit 2 (CSTF2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Cleavage stimulation factor subunit 2 (CSTF2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P33240 |
| Gene ID | 1478 |
| OMIM | 300907 |
| Alias | CSTF64,CstF-64,XLID113,Cleavage stimulation factor 64 kDa subunit,CF-1 64 kDa subunit |
| Background | Elisa kits for CSTF2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Cleavage stimulation factor subunit 2 (CSTF2) is a critical component of the cleavage stimulation factor (CstF) complex, required for the 3' end processing of pre-mRNAs through cleavage and polyadenylation. CSTF2 contains an RNA recognition motif (RRM) that specifically binds to GU-rich elements downstream of the cleavage site, ensuring accurate mRNA maturation and stability. CSTF2 interacts with CSTF1 and CSTF3 to form the heterotrimeric CstF complex, which assembles on the pre-mRNA substrate to facilitate the recruitment of other cleavage factors. Its expression is cell-cycle regulated, with levels peaking during the transition from G0 to S phase, indicating its role in cell proliferation and growth. CSTF2 also influences alternative polyadenylation, a process that regulates mRNA isoform diversity and contributes to cellular differentiation and responses to environmental signals. Dysregulation of CSTF2 has been associated with oncogenic processes, such as 3' UTR shortening in cancer cells, which can enhance the stability and translation of growth-promoting mRNAs, underscoring its significance in both normal physiology and pathology.
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