Human Chromosome 11 Open Reading Frame 51 (ANAPC15) ELISA Kit
715€ (96 tests)
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name
Human Chromosome 11 Open Reading Frame 51 (ANAPC15) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx386116
tested applications
ELISA
Description
Human Chromosome 11 Open Reading Frame 51 (ANAPC15) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase Promoting Complex Subunit 15 (ANAPC15) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Chromosome 11 Open Reading Frame 51 (ANAPC15) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.19 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P60006 |
| Gene ID | 25906 |
| OMIM | 614717 |
| Alias | ANAPC15,C11orf51,HSPC020,APC15 |
| Background | Elisa kits for ANAPC15 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANAPC15 is a core component of the Anaphase-Promoting Complex/Cyclosome (APC/C) that functions to stabilize the catalytic module of the complex. ANAPC15 interacts with ANAPC11, the RING finger subunit, and E2 ubiquitin-conjugating enzymes to support the ubiquitination of key cell cycle regulators such as cyclin B and securin. ANAPC15 ensures the proper activation of APC/C during mitosis, facilitating the degradation of substrates required for the metaphase-to-anaphase transition. Dysregulation of ANAPC15 can impair the proteolytic activity of the APC/C, resulting in defective chromosome segregation, mitotic arrest, and genomic instability. Such defects are associated with tumorigenesis and cell proliferation abnormalities. Its function as part of the catalytic core highlights ANAPC15’s essential role in maintaining cell cycle fidelity and preventing aneuploidy.
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