Chromosome 11 Open Reading Frame 51 (ANAPC15) Antibody
637€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Chromosome 11 Open Reading Frame 51 (ANAPC15) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx111651
tested applications
ELISA, WB, IHC
Description
Chromosome 11 Open Reading Frame 51 Antibody is a Rabbit Polyclonal antibody against Chromosome 11 Open Reading Frame 51.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Chromosome 11 Open Reading Frame 51 (ANAPC15) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P60006 |
| Gene ID | 25906 |
| NCBI Accession | NP_001265414.1, NM_001278485.1, NP_001265415.1, NM_001278486.1, NP_001265416.1, NM_001278487.1 |
| OMIM | 614717 |
| Alias | ANAPC15,C11orf51,HSPC020,APC15 |
| Background | Antibody anti-ANAPC15 |
| Status | RUO |
Descripción
ANAPC15 is a core component of the Anaphase-Promoting Complex/Cyclosome (APC/C) that functions to stabilize the catalytic module of the complex. ANAPC15 interacts with ANAPC11, the RING finger subunit, and E2 ubiquitin-conjugating enzymes to support the ubiquitination of key cell cycle regulators such as cyclin B and securin. ANAPC15 ensures the proper activation of APC/C during mitosis, facilitating the degradation of substrates required for the metaphase-to-anaphase transition. Dysregulation of ANAPC15 can impair the proteolytic activity of the APC/C, resulting in defective chromosome segregation, mitotic arrest, and genomic instability. Such defects are associated with tumorigenesis and cell proliferation abnormalities. Its function as part of the catalytic core highlights ANAPC15’s essential role in maintaining cell cycle fidelity and preventing aneuploidy.
Related Products
ANAPC15 antibody
Ver Producto
Recombinant Human ANAPC15
Ver Producto
Chromosome 11 Open Reading Frame 51 (ANAPC15) Antibody
Chromosome 11 Open Reading Frame 51 Antibody is a Rabbit Polyclonal antibody against Chromosome 11 Open Reading Frame 51.
Ver Producto