Human Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) ELISA Kit

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ELISA Kits

Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2)

Human

Colorimetric

Quantitative

Sandwich

0.312 ng/ml - 20 ng/ml

< 0.15 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Standard Form: Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

O00421

9034

608379

CCRL2,HCR,CKRX,CRAM,ACKR5,CRAM-A,CRAM-B,CCR11,Chemokine receptor X

Elisa Kits for: CCRL2

RUO

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) is an atypical chemokine receptor that interacts with chemerin, a chemotactic protein, but does not exhibit classical signaling functions like other chemokine receptors. CCRL2 is primarily expressed on immune cells, such as macrophages, dendritic cells, and endothelial cells, as well as on cells within the tumor microenvironment. Unlike traditional chemokine receptors that trigger intracellular signaling cascades upon ligand binding, CCRL2 functions as a decoy receptor or scavenger receptor, binding to its ligand without inducing a signaling response. Instead, CCRL2 helps to regulate chemerin levels by presenting it to other functional receptors, such as CMKLR1. CCRL2 is essential for modulating immune responses during inflammation and plays a role in controlling the migration and activation of macrophages and natural killer (NK) cells in response to chemerin. Dysregulation of CCRL2 has been implicated in diseases such as asthma, rheumatoid arthritis, and cardiovascular inflammation, where it affects leukocyte trafficking and inflammatory cytokine production. In the context of cancer, CCRL2 expression is elevated in certain tumor types, where it helps recruit immune cells to the tumor microenvironment, potentially influencing tumor immunity and progression. As a non-signaling receptor, CCRL2 provides an additional layer of regulation for the chemokine network, balancing immune responses and inflammation. Its emerging roles in immunity, inflammation, and tumor biology make CCRL2 an attractive target for research and therapeutic development in inflammatory and oncological diseases.

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