Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Antibody
292.5€ (80 µl)
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Name
Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx028870
Tested Applications
ELISA, WB
Description
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) Immunogen: KLH-conjugated synthetic peptide between 206-234 amino acids from the Central region of human CCRL2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 39.5 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00421 |
| Alias | CCRL2,HCR,CKRX,CRAM,ACKR5,CRAM-A,CRAM-B,CCR11,Chemokine receptor X |
| Background | Antibody anti-CCRL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Chemokine C-C-Motif Receptor Like Protein 2 (CCRL2) is an atypical chemokine receptor that interacts with chemerin, a chemotactic protein, but does not exhibit classical signaling functions like other chemokine receptors. CCRL2 is primarily expressed on immune cells, such as macrophages, dendritic cells, and endothelial cells, as well as on cells within the tumor microenvironment. Unlike traditional chemokine receptors that trigger intracellular signaling cascades upon ligand binding, CCRL2 functions as a decoy receptor or scavenger receptor, binding to its ligand without inducing a signaling response. Instead, CCRL2 helps to regulate chemerin levels by presenting it to other functional receptors, such as CMKLR1. CCRL2 is essential for modulating immune responses during inflammation and plays a role in controlling the migration and activation of macrophages and natural killer (NK) cells in response to chemerin. Dysregulation of CCRL2 has been implicated in diseases such as asthma, rheumatoid arthritis, and cardiovascular inflammation, where it affects leukocyte trafficking and inflammatory cytokine production. In the context of cancer, CCRL2 expression is elevated in certain tumor types, where it helps recruit immune cells to the tumor microenvironment, potentially influencing tumor immunity and progression. As a non-signaling receptor, CCRL2 provides an additional layer of regulation for the chemokine network, balancing immune responses and inflammation. Its emerging roles in immunity, inflammation, and tumor biology make CCRL2 an attractive target for research and therapeutic development in inflammatory and oncological diseases.
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