Human Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) Peptide (OVA)
442€ (100 µg)
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935106861
info@markelab.com
name
Human Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) Peptide (OVA)
category
Proteins and Peptides
provider
Abbexa
reference
abx651265
tested applications
WB, SDS-PAGE
Description
Human CCR1 Peptide (OVA) is a synthetic Human peptide conjugated to OVA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) |
| Origin | Human |
| Conjugation | OVA |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr7-Cys24 |
| Expression | Synthetic |
| Purity | > 90% |
| Size 1 | 100 µg |
| Size 2 | 200 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Size 5 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CCR1,CC CKR1,CKR1,MIP-1αR,CD191,MIP1aR,CKR-1,HM145,CMKBR1,MIP1aR,SCYAR1,Chemokine C-C-Motif Receptor 1 |
| Background | Protein CCR1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
C-C Chemokine Receptor Type 1 (CCR1) is a G-protein-coupled receptor (GPCR) primarily expressed on the surface of immune cells such as monocytes, macrophages, T lymphocytes, neutrophils, and eosinophils. CCR1 binds C-C chemokines, including CCL3 (MIP-1α), CCL5 (RANTES), and CCL14, driving immune cell chemotaxis, activation, and trafficking to sites of inflammation, infection, or tissue damage. This receptor plays a central role in the innate immune response and facilitates the migration of immune cells to areas where pathogens or damaged tissues trigger inflammatory signals. CCR1 signaling activates pathways such as MAPK, PI3K/AKT, and NF-κB, leading to cytokine secretion, increased cell adhesion, and immune cell recruitment. Dysregulated CCR1 activity is implicated in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease (IBD), where excessive recruitment of leukocytes amplifies inflammation and tissue damage. CCR1 also contributes to the pathogenesis of certain cancers, as its activation promotes tumor progression, angiogenesis, and metastasis by recruiting immune cells to the tumor microenvironment. Therapeutic strategies targeting CCR1, including small molecule antagonists and antibodies, are being developed to treat chronic inflammatory conditions and prevent tumor-associated immune infiltration. Research continues to uncover its role in infection, immunity, and cancer, highlighting its importance as a therapeutic target in immune-mediated diseases and oncology.
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