Human Cell Adhesion Molecule 1 (CADM1) Protein
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Description
Cell Adhesion Molecule 1 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cell Adhesion Molecule 1 (CADM1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 60.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg27-Val292 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BY67 |
| Gene ID | 23705 |
| OMIM | 605686 |
| Alias | BL2,ST17,IGSF4,NECL2,RA175,TSLC1,IGSF4A,Necl-2,SYNCAM,sgIGSF,sTSLC-1,synCAM1,Tumor suppressor in lung cancer 1,Nectin-like protein 2,Immunoglobulin superfamily member 4 |
| Background | Protein CADM1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CADM1, also known as synaptic cell adhesion molecule (SynCAM1), is a member of the immunoglobulin superfamily and plays a pivotal role in cell-cell adhesion, synapse formation, and immune cell interactions. It is widely expressed in the nervous system, epithelial tissues, and immune cells, mediating interactions between neurons, epithelial cells, and immune cells. CADM1 is involved in the establishment and maintenance of synaptic connections, particularly in excitatory synapses, and contributes to neuronal network stability and plasticity. It has tumor-suppressive properties, with reduced expression frequently observed in cancers such as lung adenocarcinoma, where it is associated with increased invasiveness and metastasis. CADM1 interacts with scaffolding proteins and cytoskeletal regulators, facilitating intracellular signaling pathways that regulate cell polarity, migration, and proliferation. Structural studies have identified its extracellular immunoglobulin-like domains as critical for homophilic and heterophilic interactions, enabling diverse adhesive functions. CADM1 also plays a role in the immune system by modulating mast cell adhesion and interaction with nerve fibers. Dysregulation of CADM1 has been linked to neurodevelopmental disorders and inflammatory diseases, underscoring its significance in both physiological and pathological processes.
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anti- CADM1 antibody
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer(NSCLC) cells. Interaction with CRTAM promotes natural killer(NK) cell cytotoxicity and interferon-gamma(IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly(By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
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anti- Cadm1 antibody
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer(NSCLC) cells. Interaction with CRTAM promotes natural killer(NK) cell cytotoxicity and interferon-gamma(IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Ver Producto
anti- CADM1 antibody
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer(NSCLC) cells. Interaction with CRTAM promotes natural killer(NK) cell cytotoxicity and interferon-gamma(IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly(By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Ver Producto