Human CCR4 (C-C chemokine receptor type 4) ELISA Kit
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Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 78.125-5000pg/ml |
| Sensitivity | 46.875pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P51679 |
| Alias | CCR4,CD194,ChemR13,C-C chemokine receptor 4,CC CKR4,chemokine (C-C motif) receptor 4,CC-CKR-4 |
| Background | Elisa kits for CCR4 |
| Status | RUO |
C-C Chemokine Receptor Type 4 (CCR4) is a G-protein-coupled receptor (GPCR) primarily expressed on T-helper 2 (Th2) lymphocytes, regulatory T cells (Tregs), natural killer (NK) cells, and dendritic cells. CCR4 selectively binds chemokines like CCL17 (TARC) and CCL22 (MDC), mediating immune cell migration, trafficking, and activation. It plays a significant role in directing T-cell responses during allergic inflammation and immune homeostasis. CCR4 facilitates the recruitment of Th2 cells to tissues such as the lungs, skin, and mucosal surfaces, making it a critical mediator in conditions like asthma, atopic dermatitis, and allergic rhinitis. Additionally, CCR4 is highly expressed on regulatory T cells (Tregs), which suppress immune responses and maintain tolerance, particularly in tumors, where Tregs suppress anti-tumor immunity. Elevated CCR4 expression is associated with T-cell lymphomas, including adult T-cell leukemia/lymphoma (ATLL) and cutaneous T-cell lymphoma (CTCL), where it contributes to tumor progression and immune escape. CCR4 has emerged as a therapeutic target for both autoimmune diseases and cancer. Antibodies and small-molecule antagonists targeting CCR4 are being explored to inhibit Treg recruitment in tumors, restore anti-tumor immunity, and reduce inflammation in allergic diseases. Understanding the complex interplay of CCR4 in immune responses continues to drive its role as a therapeutic target in immunotherapy and inflammatory diseases.
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