Human CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) Protein

Este producto es parte de CRADD - Death domain-containing protein CRADD
Human CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein CRADD

proveedor

Abbexa

reference

abx065745

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Death domain-containing protein CRADD, also known as RIP, is involved in mediating cellular responses to stress, particularly in the regulation of apoptosis. It contains a death domain (DD) and serves as a key adaptor protein in the signaling pathways triggered by death receptors. CRADD is known to participate in the formation of the death-inducing signaling complex (DISC) when activated by signals such as tumor necrosis factor (TNF) or Fas ligand (FasL), leading to the activation of caspases and subsequent apoptosis. In addition, CRADD has been implicated in other processes, such as inflammation and neurodegeneration. Its expression and function are tightly regulated and have been linked to both cell survival and death in different contexts.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 24.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Glu199 Tag: N-terminal His tag


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

CRADD


dry ice

No


availability

Shipped within 5-12 working days.


alias

RAIDD, MRT34,CASP2,RIPK1,CRADD


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reactivity

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