Human CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein CRADD
proveedor
Abbexareference
abx065745Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Death domain-containing protein CRADD, also known as RIP, is involved in mediating cellular responses to stress, particularly in the regulation of apoptosis. It contains a death domain (DD) and serves as a key adaptor protein in the signaling pathways triggered by death receptors. CRADD is known to participate in the formation of the death-inducing signaling complex (DISC) when activated by signals such as tumor necrosis factor (TNF) or Fas ligand (FasL), leading to the activation of caspases and subsequent apoptosis. In addition, CRADD has been implicated in other processes, such as inflammation and neurodegeneration. Its expression and function are tightly regulated and have been linked to both cell survival and death in different contexts.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
CASP2 And RIPK1 Domain Containing Adaptor With Death Domain Protein (CRADD)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 24.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Glu199 Tag: N-terminal His tag
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
CRADD
dry ice
No
availability
Shipped within 5-12 working days.
alias
RAIDD, MRT34,CASP2,RIPK1,CRADD
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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