Human Cartilage Oligomeric Matrix Protein (COMP) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein COMP
proveedor
Abbexareference
abx166151Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Cartilage Oligomeric Matrix Protein (COMP) Protein is a recombinant Human protein expressed in a prokaryotic expression system (E. coli).
Background
COMP is a non-collagenous extracellular matrix protein primarily expressed in cartilage, tendons, and ligaments where it plays a key role in maintaining tissue structure and mechanical integrity COMP interacts with collagen fibrils and other matrix components to facilitate fibril assembly and stabilize the extracellular matrix COMP also functions as a chaperone during collagen secretion, promoting proper folding and export from chondrocytes Mutations in COMP are associated with skeletal dysplasias such as pseudoachondroplasia and multiple epiphyseal dysplasia, which result in abnormal cartilage development, joint pain, and short stature COMP overexpression has been observed in osteoarthritis and rheumatoid arthritis, where its elevated levels contribute to cartilage degradation and inflammation COMP is also implicated in cardiovascular diseases where it regulates vascular smooth muscle cell function and extracellular matrix remodeling
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Cartilage Oligomeric Matrix Protein (COMP)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration of ≤ 0.1 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 16.5 kDa Observed MW (SDS-PAGE): 16 kDa Concentration: Prior to lyophilization: 50 µg/ml Sequence Fragment: Ser123-His240 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
COMP
dry ice
No
availability
Shipped within 5-7 working days.
alias
MED,CTS2,EDM1,EPD1,TSP5,PSACH,THBS5,TSP-5,Thrombospondin-5
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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