Human Caldesmon (CALD1) ELISA Kit
546€ (96 tests)
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name
Human Caldesmon (CALD1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx051510
tested applications
ELISA
Description
Human Caldesmon (CALD1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Caldesmon (CALD1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Caldesmon (CALD1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.2 ng/ml - 10 ng/ml |
| Sensitivity | 0.09 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q05682 |
| Gene ID | 800 |
| NCBI Accession | NP_004333.1, NM_004342.6, NP_149129.2, NM_033138.3 |
| OMIM | 114213 |
| Alias | CALD1, CDM, H-CAD, HCAD, L-CAD caldesmon |
| Background | Elisa kits for CALD1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CALD1 (Caldesmon 1) is a versatile actin-binding protein predominantly expressed in smooth muscle and non-muscle cells, where it plays a key role in modulating cytoskeletal dynamics and cellular contractility. CALD1 interacts with actin filaments, myosin, tropomyosin, and calmodulin, acting as a regulatory mediator of actomyosin interactions crucial for cellular processes such as contraction, migration, and shape changes. In smooth muscle cells, CALD1 contributes to the regulation of contraction by inhibiting the ATPase activity of myosin in a calcium-calmodulin-dependent manner, thereby modulating muscle tone and elasticity. In non-muscle cells, it is implicated in stabilizing the cytoskeleton and facilitating cell motility, often in response to signaling cascades that control cell migration and adhesion. CALD1 has also been associated with cancer progression, where its expression is frequently altered, contributing to tumor invasiveness and metastasis by influencing cytoskeletal reorganization and cellular dynamics. Its phosphorylation state, regulated by various kinases, fine-tunes its interaction with actin and myosin, enabling precise control over cytoskeletal remodeling. These multifunctional attributes make CALD1 a critical player in maintaining cellular integrity and adaptability across different physiological and pathological contexts.
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