CALD1 antibody

Este producto es parte de CALD1 - Caldesmon
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935106861
info@markelab.com
name
CALD1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01199
tested applications
ELISA, WB, IF, IHC

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
caldesmon 1 (CALD1)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
61-65kd,70-80kd
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IF, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q05682
Alias
CALD1, CDM, H-CAD, HCAD, L-CAD caldesmon
Background
Antibody anti-CALD1
Status
RUO
Note
Mol. Weight 61-65 kDa, 70-80 kDa

CALD1 (Caldesmon 1) is a versatile actin-binding protein predominantly expressed in smooth muscle and non-muscle cells, where it plays a key role in modulating cytoskeletal dynamics and cellular contractility. CALD1 interacts with actin filaments, myosin, tropomyosin, and calmodulin, acting as a regulatory mediator of actomyosin interactions crucial for cellular processes such as contraction, migration, and shape changes. In smooth muscle cells, CALD1 contributes to the regulation of contraction by inhibiting the ATPase activity of myosin in a calcium-calmodulin-dependent manner, thereby modulating muscle tone and elasticity. In non-muscle cells, it is implicated in stabilizing the cytoskeleton and facilitating cell motility, often in response to signaling cascades that control cell migration and adhesion. CALD1 has also been associated with cancer progression, where its expression is frequently altered, contributing to tumor invasiveness and metastasis by influencing cytoskeletal reorganization and cellular dynamics. Its phosphorylation state, regulated by various kinases, fine-tunes its interaction with actin and myosin, enabling precise control over cytoskeletal remodeling. These multifunctional attributes make CALD1 a critical player in maintaining cellular integrity and adaptability across different physiological and pathological contexts.

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