Human Cadherin, Neuronal (CDH2) CLIA Kit

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Especificaciones del producto

CLIA Kits

Cadherin, Neuronal (CDH2)

Human

Chemiluminescent

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

< 0.055 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Standard: Lyophilized

CLIA

Serum, plasma, tissue homogenates and other biological fluids.

Shipped within 5-20 working days.

Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Cadherin-2,CDHN,NCAD,ACOGS,ADHD8,CD325,ARVD14,CDw325,Neural cadherin,N-cadherin

CLIA Kits CDH2

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.  The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.  Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Cadherin 2 (CDH2), also known as N-cadherin (neural cadherin), is a calcium-dependent cell adhesion molecule that belongs to the classical cadherin family. This protein is primarily expressed in neural tissue, muscle, and endothelial cells, facilitating cell-cell adhesion that is crucial for the organization and stability of various tissues, particularly during development. CDH2 mediates homophilic cell adhesion by binding to other N-cadherin molecules on neighboring cells, helping establish stable cellular contacts necessary for tissue integrity and function. Unlike CDH1, which is primarily expressed in epithelial cells, CDH2 is prevalent in mesenchymal and neural cell types and is integral to processes like embryogenesis, neural development, and wound healing. N-cadherin’s role extends beyond basic cell adhesion, as it is actively involved in signaling pathways that regulate cell migration, differentiation, and survival. In particular, CDH2 is essential during the development of the nervous system, heart, and vasculature, contributing to the morphogenesis of organs and the maintenance of neuronal connections. Additionally, CDH2 expression has significant implications in cancer progression and metastasis, particularly through the process of epithelial-mesenchymal transition (EMT), where it replaces CDH1 as cells transition to a more migratory, invasive phenotype. This behavior makes CDH2 a critical molecule not only in normal development but also in disease progression.

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