Human CD209 Antigen (CD209) ELISA Kit
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Description
Human C-Type Lectin Domain Family 4 Member L (CD209) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human C-Type Lectin Domain Family 4 Member L (CD209) concentrations in serum, plasma and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | CD209 Antigen (CD209) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9NNX6 |
| Alias | C-type lectin domain family 4 member L,CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1,hDC-SIGN,Dendritic cell-specific ICAM-3-grabbing non-integrin 1,CD209 antigen |
| Background | Elisa kits for CD209 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CD209, commonly known as DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin), is a type II transmembrane protein receptor primarily expressed on the surface of dendritic cells (DCs) and some macrophage subsets. It plays a crucial role in the immune system by mediating pathogen recognition, cellular adhesion, and antigen capture. CD209 is a member of the C-type lectin receptor (CLR) family and exhibits high affinity for mannose-rich glycans, a feature that enables it to bind to a range of microbial structures, facilitating the immune response against pathogens. One of CD209's defining characteristics is its ability to recognize pathogen-associated molecular patterns (PAMPs), which are specific carbohydrate patterns on pathogens. By binding to these patterns, CD209 captures and internalizes pathogens, aiding in their processing and subsequent antigen presentation to T cells. The receptor is particularly relevant in the context of HIV, Mycobacterium tuberculosis, Ebola, and Dengue virus, as it can interact with these pathogens and contribute to their immune response or facilitate viral entry in certain cases.
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CD209 antibody
Pathogen-recognition receptor expressed on the surface of immature dendritic cells(DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2(PubMed:11799126, PubMed:12502850, PubMed:1518869). Acts as an attachment receptor for ebolavirus(PubMed:12502850, PubMed:12504546). Acts as an attachment receptor for cytomegalovirus(PubMed:12433371, PubMed:22496863). Acts as an attachment receptor for HCV(PubMed:15371595, PubMed:16816373). Acts as an attachment receptor for dengue virus(PubMed:12682107). Acts as an attachment receptor for measles virus(PubMed:16537615). Acts as an attachment receptor for herpes simplex virus 1(PubMed:18796707). Acts as an attachment receptor for Influenzavirus A(PubMed:21191006). Acts as an attachment receptor for SARS coronavirus(PubMed:15140961). Acts as an attachment receptor for Japanese encephalitis virus(PubMed:24623090). Acts as an attachment receptor for Lassa virus(PubMed:23966408). Acts as an attachment receptor for marburg virusn(PubMed:15479853). Acts as an attachment receptor for Respiratory syncytial virus(PubMed:22090124). Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus(PubMed:21767814). Acts as an attachment receptor for west-nile virus(PubMed:16415006). Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA(PubMed:16379498). Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule(PubMed:16092920, PubMed:21203928).
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