Human Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Protein
234€ (10 µg)
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name
Human Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167106
tested applications
WB, SDS-PAGE
Description
ATP Binding Cassette Transporter G2 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 35.0 kDa Observed MW (SDS-PAGE): 35 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Pro290 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ABC15,ABCP BCRP,BCRP1 BMDP,CD338,CDw338 |
| Background | Protein ABCG2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ABCG2, also known as the breast cancer resistance protein (BCRP), is a well-characterized ATP-binding cassette transporter involved in drug efflux and xenobiotic clearance. It is highly expressed in barrier tissues such as the intestine, liver, kidneys, and blood-brain barrier, where it protects cells by exporting a wide range of substrates, including drugs, toxins, and endogenous metabolites. ABCG2 plays a pivotal role in pharmacokinetics, influencing drug absorption, distribution, and elimination. It is also critical in stem cell biology, where it acts as a marker for side population cells due to its role in drug resistance and dye efflux. Overexpression of ABCG2 is a major contributor to multidrug resistance in cancer, as it actively pumps chemotherapeutic agents out of tumor cells, reducing their efficacy. Structurally, ABCG2 is a half-transporter that forms functional homodimers to mediate ATP-driven substrate transport. Dysregulation of ABCG2 has been linked to diseases such as gout and certain cancers, making it a target of interest in oncology and pharmacology.
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