Human Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Human Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168253
tested applications
WB, SDS-PAGE
Description
Breast Cancer Anti-Estrogen Resistance 3 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 60.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp548-Pro818 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | BCAR3, NSP2, SH2D3B, breast cancer anti-estrogen resistance 3, AND-34, NSP family adaptor protein, BCAR3 adaptor protein, NSP family member, MIG7 |
| Background | Protein BCAR3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
BCAR3, also known as Breast Cancer Anti-Estrogen Resistance Protein 3, is involved in the development of resistance to anti-estrogen therapies in breast cancer, much like its family members BCAR1 and BCAR2. BCAR3 has been shown to participate in signaling pathways that affect cell survival and migration. This protein is often implicated in the progression of cancer cells from an estrogen-dependent to an estrogen-independent state, allowing them to proliferate and survive despite the presence of estrogen inhibitors. BCAR3’s interaction with other molecular players in cell signaling, such as those controlling cytoskeletal reorganization, further contributes to cancer cell invasion and metastasis. Targeting BCAR3 may offer new therapeutic approaches for overcoming resistance in estrogen receptor-positive breast cancer, providing more effective treatments for patients with advanced disease. Its role in cancer progression and therapy resistance makes BCAR3 an important subject of ongoing research in oncology.
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