Human Bone Marrow Stromal Antigen 2 (BST2) Protein
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Description
Human Bone Marrow Stromal Antigen 2 (BST2) protein is a recombinant Human protein expressed in 293F cells.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Bone Marrow Stromal Antigen 2 (BST2) |
| Host | 293F cells |
| Assay Type | Activity: Not tested Sequence Fragment: Asn49-Ser161 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 14.2 kDa Observed MW (SDS-PAGE): 24 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q10589 |
| Gene ID | 684 |
| Background | Protein BST2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU per 1 µg (determined by the LAL method) Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
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Human BST2 (Bone marrow stromal antigen 2) ELISA Kit
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BST2 antibody
IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1(HIV-1), human immunodeficiency virus type 2(HIV-2), simian immunodeficiency viruses(SIVs), equine infectious anemia virus(EIAV), feline immunodeficiency virus(FIV), prototype foamy virus(PFV), Mason-Pfizer monkey virus(MPMV), human T-cell leukemia virus type 1(HTLV-1), Rous sarcoma virus(RSV) and murine leukemia virus(MLV), flavivirideae: hepatitis C virus(HCV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), arenaviridae: lassa virus(LASV) and machupo virus(MACV), herpesviridae: kaposis sarcoma-associated herpesvirus(KSHV), rhabdoviridae: vesicular stomatitis virus(VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities. Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu. Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2.
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