Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx525007
tested applications
ELISA
Description
Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O95395 |
| Gene ID | 9245 |
| OMIM | 606836 |
| Alias | C2GnT-mucin type,C2GnT-M,hC2GnT-M,Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase ,C2/4GnT |
| Background | Elisa kits for GCNT3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Glucosaminyl (N-acetyl) transferase 3 (GCNT3) is a key enzyme responsible for the synthesis of core 2 O-glycans, vital for mucin production and glycan branching on glycoproteins GCNT3 is primarily expressed in mucin-secreting epithelial cells of the gastrointestinal, respiratory, and reproductive tracts, where it regulates epithelial barrier integrity, mucus production, and protection against microbial invasion It has a critical role in modulating inflammatory responses, with altered GCNT3 activity implicated in diseases like colitis, Crohn’s disease, and chronic inflammation of mucosal surfaces GCNT3 also functions as a tumor suppressor, with reduced expression linked to cancers such as colorectal, pancreatic, and gastric cancers where disrupted glycosylation promotes tumor growth, invasion, and metastasis Emerging studies suggest GCNT3 regulates immune responses by maintaining epithelial glycan patterns essential for immune defense pathways Its role in glycan biosynthesis highlights its importance in epithelial protection, mucosal immunity, and tumor suppression pathways
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