Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits GCNT3
proveedor
Abbexareference
abx525007Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Glucosaminyl (N-acetyl) transferase 3 (GCNT3) is a key enzyme responsible for the synthesis of core 2 O-glycans, vital for mucin production and glycan branching on glycoproteins GCNT3 is primarily expressed in mucin-secreting epithelial cells of the gastrointestinal, respiratory, and reproductive tracts, where it regulates epithelial barrier integrity, mucus production, and protection against microbial invasion It has a critical role in modulating inflammatory responses, with altered GCNT3 activity implicated in diseases like colitis, Crohn’s disease, and chronic inflammation of mucosal surfaces GCNT3 also functions as a tumor suppressor, with reduced expression linked to cancers such as colorectal, pancreatic, and gastric cancers where disrupted glycosylation promotes tumor growth, invasion, and metastasis Emerging studies suggest GCNT3 regulates immune responses by maintaining epithelial glycan patterns essential for immune defense pathways Its role in glycan biosynthesis highlights its importance in epithelial protection, mucosal immunity, and tumor suppression pathways
Características del producto
category
ELISA Kits
immunogen target
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
C2GnT-mucin type,C2GnT-M,hC2GnT-M,Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase ,C2/4GnT
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
GCNT3
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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