Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 3 (GCNT3) Antibody
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935106861
info@markelab.com
Precio
281.25€ (80 µl)
Antibody anti-GCNT3
proveedor
Abbexareference
abx029108Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.
Background
Glucosaminyl (N-acetyl) transferase 3 (GCNT3) is a key enzyme responsible for the synthesis of core 2 O-glycans, vital for mucin production and glycan branching on glycoproteins GCNT3 is primarily expressed in mucin-secreting epithelial cells of the gastrointestinal, respiratory, and reproductive tracts, where it regulates epithelial barrier integrity, mucus production, and protection against microbial invasion It has a critical role in modulating inflammatory responses, with altered GCNT3 activity implicated in diseases like colitis, Crohn’s disease, and chronic inflammation of mucosal surfaces GCNT3 also functions as a tumor suppressor, with reduced expression linked to cancers such as colorectal, pancreatic, and gastric cancers where disrupted glycosylation promotes tumor growth, invasion, and metastasis Emerging studies suggest GCNT3 regulates immune responses by maintaining epithelial glycan patterns essential for immune defense pathways Its role in glycan biosynthesis highlights its importance in epithelial protection, mucosal immunity, and tumor suppression pathways
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase 3 (GCNT3)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified through a protein A column, followed by peptide affinity purification.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
GCNT3
dry ice
No
availability
Shipped within 5-10 working days.
alias
C2GnT-mucin type,C2GnT-M,hC2GnT-M,Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase ,C2/4GnT
uniprot id
note
This product is for research use only.
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