Human BCL2/Adenovirus E1B 19 kDa Protein-Interacting Protein 3 (BNIP3) Protein
208€ (10 µg)
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935106861
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name
Human BCL2/Adenovirus E1B 19 kDa Protein-Interacting Protein 3 (BNIP3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692900
tested applications
SDS-PAGE
Description
Human BNIP3 Protein is a recombinant protein from Human produced in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | BNIP3 |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 20.6 kDa Observed MW: 65 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Lys163 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH7.4, containing 0.01% Sarcosyl and 5% Trehalose. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q12983 |
| Alias | NIP3,HABON,BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
| Background | Protein BNIP3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
BCL2 interacting protein 3 (BNIP3) is a pro-apoptotic member of the Bcl-2 family that plays a key role in regulating cell death, particularly in response to cellular stress BNIP3 functions by interacting with anti-apoptotic Bcl-2 family members, promoting mitochondrial outer membrane permeabilization, and facilitating the release of pro-apoptotic factors such as cytochrome c from the mitochondria This release activates the caspase cascade, triggering apoptosis BNIP3 is particularly involved in regulating hypoxia-induced cell death and autophagy, which are essential for cellular adaptation to low oxygen levels and nutrient stress Dysregulation of BNIP3 has been linked to various diseases, including cancer and neurodegenerative disorders, where altered expression of BNIP3 contributes to uncontrolled cell survival, tumor progression, and impaired cellular homeostasis BNIP3's role in mitochondrial function and its involvement in the hypoxic response make it an important factor in regulating cell death and adaptation to environmental stresses
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