Human Bcl2 Like Protein 11 (BCL2L11) Protein
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Description
Recombinant Bcl2 Like Protein 11 (BCL2L11) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Bcl2 Like Protein 11 (BCL2L11) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 17.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala2-Arg120 Tag: N-terminal His tag and T7 tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43521 |
| Alias | BAM,BIM,BOD,Bcl-2-like protein 11,Bcl2-interacting mediator of cell death |
| Background | Protein BCL2L11 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
BCL2 like 11 (BCL2L11), also known as BIM, is a pro-apoptotic protein belonging to the Bcl-2 family, which regulates cell death by controlling mitochondrial outer membrane permeabilization BCL2L11 plays a central role in initiating apoptosis in response to cellular stress, such as DNA damage, oxidative stress, or growth factor deprivation By promoting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, BCL2L11 triggers the activation of caspases, leading to programmed cell death BCL2L11’s activity is tightly regulated by interactions with other Bcl-2 family members, particularly anti-apoptotic proteins like BCL2, which prevent its activation In cancers, BCL2L11 is often downregulated, allowing tumor cells to evade apoptosis and continue to proliferate BCL2L11 is also implicated in immune system regulation, where it controls the survival and activation of immune cells, particularly in T-cell homeostasis Its pro-apoptotic function and regulation of immune responses make BCL2L11 an essential player in maintaining cellular integrity and in controlling the balance between cell survival and death
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