Human B-Cell Differentiation Antigen CD72 (CD72) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein CD72
proveedor
Abbexareference
abx065939Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Cluster Of Differentiation 72 (CD72) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
CD72 is a type II transmembrane glycoprotein belonging to the C-type lectin superfamily. It is mainly expressed on the surface of B cells, as well as some other immune cells such as dendritic cells. CD72 serves as a negative regulator of B cell receptor (BCR) signaling, modulating immune responses by attenuating excessive B cell activation and preventing autoimmunity. CD72 interacts with protein tyrosine phosphatases, including SHP-1 and SHP-2, through its immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic domain. When activated, CD72 negatively regulates BCR signaling, contributing to the maintenance of immune tolerance and B cell homeostasis. Given its central role in B cell regulation, CD72 is involved in autoimmune diseases, chronic inflammatory conditions, and lymphomas.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
B-Cell Differentiation Antigen CD72 (CD72)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 25.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu169-Asp359 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
CD72
dry ice
No
availability
Shipped within 5-7 working days.
alias
LYB2,CD72b,B-cell differentiation antigen CD72
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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
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Abbexareference
abx065939Tested Applications
WB, SDS-PAGEstatus
RUORecombinant Cluster Of Differentiation 72 (CD72) is a recombinant Human protein produced in a Prokaryotic expression sys...
234€ (10 µg)
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