Human B-Cell Differentiation Antigen CD72 (CD72) Protein

Este producto es parte de CD72 - CD72 molecule
Human B-Cell Differentiation Antigen CD72 (CD72) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein CD72

proveedor

Abbexa

reference

abx065939

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Cluster Of Differentiation 72 (CD72) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

CD72 is a type II transmembrane glycoprotein belonging to the C-type lectin superfamily. It is mainly expressed on the surface of B cells, as well as some other immune cells such as dendritic cells. CD72 serves as a negative regulator of B cell receptor (BCR) signaling, modulating immune responses by attenuating excessive B cell activation and preventing autoimmunity. CD72 interacts with protein tyrosine phosphatases, including SHP-1 and SHP-2, through its immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic domain. When activated, CD72 negatively regulates BCR signaling, contributing to the maintenance of immune tolerance and B cell homeostasis. Given its central role in B cell regulation, CD72 is involved in autoimmune diseases, chronic inflammatory conditions, and lymphomas.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

B-Cell Differentiation Antigen CD72 (CD72)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 25.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu169-Asp359 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

CD72


dry ice

No


availability

Shipped within 5-7 working days.


alias

LYB2,CD72b,B-cell differentiation antigen CD72


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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Tested Applications

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Recombinant Cluster Of Differentiation 72 (CD72) is a recombinant Human protein produced in a Prokaryotic expression sys...

234€ (10 µg)

Ver más