Human Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Protein (Active)
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935106861
info@markelab.com
Precio
225€ (1 µg)
Protein TNFSF13B
proveedor
Abbexareference
abx260381Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Protein is an active recombinant human cytokine expressed in Nicotiana benthamiana plant.
Background
TNFSF13B, commonly known as BAFF (B-cell activating factor), is a cytokine that belongs to the tumor necrosis factor (TNF) superfamily and is critical for B cell survival, maturation, and immune function. This ligand is primarily produced by myeloid cells, such as monocytes, macrophages, and dendritic cells, but can also be secreted by activated T cells. BAFF plays a pivotal role in maintaining peripheral B cell populations, supporting antibody production, and promoting immune tolerance. It interacts with specific receptors on B cells and related immune cells, including BAFF-R, TACI (Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor), and BCMA (B Cell Maturation Antigen), to initiate intracellular signaling pathways crucial for B cell homeostasis and function. Dysregulation of BAFF expression or receptor binding is associated with autoimmune diseases, such as systemic lupus erythematosus (SLE), multiple sclerosis, and rheumatoid arthritis.
Características del producto
category
Proteins and Peptides
origin
Human
host
Plant
immunogen target
Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B)
host
Plant
conjugation
Unconjugated
form
Lyophilized
tested applications
SDS-PAGE
size 1
1 µg
size 2
5 µg
size 3
100 µg
expression
Recombinant
purity
> 97% (SDS-PAGE)
purification
Purified by standard chromatographic techniques.
buffer
Prior to lyophilization: 20 mM PBS, pH 7, containing 0.2 M NaCl.
storage
Stable at room temperature for up to 3 weeks. Store below -18 °C for long-term storage. Upon reconstitution, store at 4 °C for up to 7 days and store below -18 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
or code
TNFSF13B
dry ice
No
availability
Shipped within 5-10 working days.
alias
Tumor necrosis factor ligand superfamily member 13B,DTL,BAFF,BLYS,CD257,TALL1,THANK,ZTNF4,TALL-1,TNLG7A,TNFSF20,B lymphocyte stimulator,BLyS,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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