Human ATP Binding Cassette Transporter C9 (ABCC9) Protein
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Description
Human ATP Binding Cassette Transporter C9 (ABCC9) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATP Binding Cassette Transporter C9 (ABCC9) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ABC37,ATFB12,CANTU,CMD1O,IDMYS,SUR2 |
| Background | Protein ABCC9 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ATP Binding Cassette Subfamily C Member 9 (ABCC9) encodes the sulfonylurea receptor 2 (SUR2), a key regulatory subunit of K-ATP channels found in cardiac, skeletal muscle, and smooth muscle tissues. These channels link cellular metabolism to electrical activity by sensing intracellular ATP and ADP levels, thereby regulating vascular tone and myocardial contractility. ABCC9 mutations have been associated with various conditions, including Cantu syndrome, characterized by hypertrichosis, osteochondrodysplasia, and cardiac abnormalities. The protein also plays a role in ischemic tolerance by modulating mitochondrial function and protecting tissues from damage during ischemic episodes. Pharmacologically, ABCC9 is a target for potassium channel openers, drugs that induce vasodilation and are used in the management of hypertension and angina. Its involvement in metabolic disorders and vascular diseases underscores its therapeutic significance.
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