Human ATP Binding Cassette Transporter C9 (ABCC9) CLIA Kit
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Description
Human ATP Binding Cassette Transporter C9 (ABCC9) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | ATP Binding Cassette Transporter C9 (ABCC9) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.132 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ABC37,ATFB12,CANTU,CMD1O,IDMYS,SUR2 |
| Background | CLIA Kits ABCC9 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ATP Binding Cassette Subfamily C Member 9 (ABCC9) encodes the sulfonylurea receptor 2 (SUR2), a key regulatory subunit of K-ATP channels found in cardiac, skeletal muscle, and smooth muscle tissues. These channels link cellular metabolism to electrical activity by sensing intracellular ATP and ADP levels, thereby regulating vascular tone and myocardial contractility. ABCC9 mutations have been associated with various conditions, including Cantu syndrome, characterized by hypertrichosis, osteochondrodysplasia, and cardiac abnormalities. The protein also plays a role in ischemic tolerance by modulating mitochondrial function and protecting tissues from damage during ischemic episodes. Pharmacologically, ABCC9 is a target for potassium channel openers, drugs that induce vasodilation and are used in the management of hypertension and angina. Its involvement in metabolic disorders and vascular diseases underscores its therapeutic significance.
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