Human ATP Binding Cassette Transporter C5 (ABCC5) Protein
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Description
Human ATP Binding Cassette Transporter C5 (ABCC5) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATP Binding Cassette Transporter C5 (ABCC5) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ABC33,EST277145,MOAT-C,MOATC |
| Background | Protein ABCC5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ATP Binding Cassette Subfamily C Member 5 (ABCC5), also known as multidrug resistance-associated protein 5 (MRP5), plays a crucial role in the transport of various substrates across cellular membranes. This protein is part of the ATP-binding cassette (ABC) transporter family and utilizes ATP hydrolysis to facilitate the export of organic anions and cyclic nucleotides like cGMP and cAMP from cells. ABCC5 is expressed in multiple tissues, including the liver, kidneys, and brain, where it contributes to cellular detoxification and protection against xenobiotics and endogenous metabolites. Furthermore, ABCC5 is implicated in drug resistance, particularly in cancer therapy, by actively exporting chemotherapeutic agents, thereby reducing their intracellular accumulation. Research also suggests its role in regulating vascular smooth muscle tone and platelet aggregation, highlighting its physiological significance beyond drug transport. Polymorphisms in ABCC5 may influence individual variability in drug responses and susceptibility to certain diseases, making it a target of interest for pharmacogenomics.
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