Human ATP Binding Cassette Transporter C2 (ABCC2) Protein

Este producto es parte de ABCC - ATP binding cassette subfamily C
Human ATP Binding Cassette Transporter C2 (ABCC2) Protein

Pida mas información

935106861

info@markelab.com

Precio

225€ (10 µg)

Protein ABCC2

proveedor

Abbexa

reference

abx166886

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

ATP Binding Cassette Transporter C2 Protein is a recombinant Human protein expressed in E. coli.


Background

ABCC2, also known as multidrug resistance-associated protein 2 (MRP2), is an ATP-binding cassette transporter primarily expressed on the apical membrane of hepatocytes, where it plays a vital role in bile secretion and detoxification. ABCC2 mediates the ATP-dependent transport of conjugated bilirubin, xenobiotics, and drug metabolites into bile, contributing to the excretion of potentially harmful compounds. It is also expressed in other tissues, such as the kidney and intestine, where it supports renal and intestinal excretion. Mutations in ABCC2 are associated with Dubin-Johnson syndrome, a rare inherited disorder characterized by impaired bilirubin transport and conjugated hyperbilirubinemia. ABCC2’s role in drug efflux and detoxification makes it a significant player in drug pharmacokinetics, impacting drug absorption, distribution, and elimination.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

ATP Binding Cassette Transporter C2 (ABCC2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

1 mg


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCC2


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABC30,CMOAT,DJS,MRP2,cMRP


note

This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.


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