Human ATP Binding Cassette Transporter C2 (ABCC2) Protein
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935106861
info@markelab.com
Precio
225€ (10 µg)
Protein ABCC2
proveedor
Abbexareference
abx166886Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
ATP Binding Cassette Transporter C2 Protein is a recombinant Human protein expressed in E. coli.
Background
ABCC2, also known as multidrug resistance-associated protein 2 (MRP2), is an ATP-binding cassette transporter primarily expressed on the apical membrane of hepatocytes, where it plays a vital role in bile secretion and detoxification. ABCC2 mediates the ATP-dependent transport of conjugated bilirubin, xenobiotics, and drug metabolites into bile, contributing to the excretion of potentially harmful compounds. It is also expressed in other tissues, such as the kidney and intestine, where it supports renal and intestinal excretion. Mutations in ABCC2 are associated with Dubin-Johnson syndrome, a rare inherited disorder characterized by impaired bilirubin transport and conjugated hyperbilirubinemia. ABCC2’s role in drug efflux and detoxification makes it a significant player in drug pharmacokinetics, impacting drug absorption, distribution, and elimination.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
ATP Binding Cassette Transporter C2 (ABCC2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCC2
dry ice
No
availability
Shipped within 5-7 working days.
alias
ABC30,CMOAT,DJS,MRP2,cMRP
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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