Human ATP Binding Cassette Transporter C2 (ABCC2) Protein

234€ (10 µg)
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935106861
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name
Human ATP Binding Cassette Transporter C2 (ABCC2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166886
tested applications
WB, SDS-PAGE
Description
ATP Binding Cassette Transporter C2 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | ATP Binding Cassette Transporter C2 (ABCC2) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 29.6 kDa Observed MW (SDS-PAGE): 30 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile1300-Glu1534 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 95% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | ABC30,CMOAT,DJS,MRP2,cMRP |
Background | Protein ABCC2 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ABCC2, also known as multidrug resistance-associated protein 2 (MRP2), is an ATP-binding cassette transporter primarily expressed on the apical membrane of hepatocytes, where it plays a vital role in bile secretion and detoxification. ABCC2 mediates the ATP-dependent transport of conjugated bilirubin, xenobiotics, and drug metabolites into bile, contributing to the excretion of potentially harmful compounds. It is also expressed in other tissues, such as the kidney and intestine, where it supports renal and intestinal excretion. Mutations in ABCC2 are associated with Dubin-Johnson syndrome, a rare inherited disorder characterized by impaired bilirubin transport and conjugated hyperbilirubinemia. ABCC2’s role in drug efflux and detoxification makes it a significant player in drug pharmacokinetics, impacting drug absorption, distribution, and elimination.
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