Human ATP Binding Cassette Transporter C11 (ABCC11) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human ABCC11 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATP Binding Cassette Transporter C11 (ABCC11) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 30.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile1141-Arg1382 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96J66 |
| Alias | EWWD,MRP8,WW |
| Background | Protein ABCC11 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ATP-binding cassette subfamily C member 11 (ABCC11), also known as multidrug resistance-associated protein 8 (MRP8), is an ATP-dependent transporter involved in the efflux of various organic anions, including bile acids, cyclic nucleotides, and conjugated steroid hormones. It is highly expressed in apocrine glands, liver, and breast tissue, playing a role in physiological processes like bile acid secretion and earwax type determination. ABCC11 has clinical significance in drug transport and metabolism, with variants linked to differences in drug sensitivity and cancer susceptibility. Mutations in ABCC11 are associated with traits like dry vs. wet earwax and body odor. It has two transmembrane and two nucleotide-binding domains typical of ABC transporters.
Related Products
ATP Binding Cassette Subfamily C Member 11 (ABCC11) Antibody
ABCC11 Antibody is a Rabbit Polyclonal Antibody against ABCC11.
Ver Producto
ATP Binding Cassette Subfamily C Member 11 (ABCC11) Antibody
ABCC11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1.
Ver Producto
ATP Binding Cassette Transporter C11 (ABCC11) Antibody
ABCC11 Antibody is a Rabbit Polyclonal against ABCC11.
Ver Producto