Human ATP Binding Cassette Subfamily G Member 1 (ABCG1) Protein

Este producto es parte de ABCG - ATP Binding Cassette Subfamily G
Human ATP Binding Cassette Subfamily G Member 1 (ABCG1) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein ABCG1

proveedor

Abbexa

reference

abx065475

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant ATP Binding Cassette Transporter G1 (ABCG1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ABCG1 is a transmembrane ATP-binding cassette transporter that plays a critical role in cellular cholesterol and lipid homeostasis. It is primarily involved in the efflux of cholesterol and phospholipids to high-density lipoprotein (HDL) particles, facilitating reverse cholesterol transport and preventing intracellular lipid accumulation. ABCG1 is ubiquitously expressed but is most active in macrophages, endothelial cells, and the liver, where it regulates cholesterol levels and protects cells from lipid toxicity. Structurally, ABCG1 contains nucleotide-binding domains that hydrolyze ATP to drive lipid transport across membranes. Dysregulation of ABCG1 expression has been implicated in atherosclerosis, as impaired cholesterol efflux can lead to foam cell formation in arterial walls. ABCG1 is also involved in modulating inflammation and oxidative stress, highlighting its protective role in cardiovascular health. Furthermore, ABCG1 expression is influenced by nuclear receptors such as LXR (liver X receptor), which coordinate lipid metabolism and inflammatory responses, underscoring its importance in lipid regulatory networks and metabolic diseases.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

ATP Binding Cassette Subfamily G Member 1 (ABCG1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 27.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe79-Gly312 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCG1


dry ice

No


availability

Shipped within 5-7 working days.


alias

BCC7,BMFS5,LFS1,P53,TRP53,ABC8, WHITE1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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