Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) Protein

Este producto es parte de ABCB - ATP binding cassette subfamily B member
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208€ (10 µg)

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935106861
info@markelab.com
name
Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650380
tested applications
WB, SDS-PAGE

Description

Human ABCB6 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
ATP-Binding Cassette Sub-Family B Member 6 (ABCB6)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 31.1 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ile590-Arg842
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NP58
Gene ID
10058
NCBI Accession
NP_005680.1, NM_005689.2
OMIM
111600
Alias
LAN,MTABC3
Background
Protein ABCB6
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ABCB6 is a mitochondrial ATP-binding cassette transporter critical for the transport of porphyrins and precursors involved in heme biosynthesis. Localized to the outer mitochondrial membrane, ABCB6 facilitates the uptake of coproporphyrinogen III, a precursor in the heme biosynthesis pathway, enabling its conversion to protoporphyrin IX within mitochondria. ABCB6 is highly expressed in erythroid cells, liver, and other tissues with high heme demands, supporting processes such as oxygen transport and detoxification. In addition to its role in heme production, ABCB6 is involved in the cellular response to oxidative stress and drug metabolism. Mutations in ABCB6 have been associated with disorders like familial pseudohyperkalemia and dyschromatosis universalis hereditaria, affecting red blood cells and pigmentation, respectively. Dysregulation of ABCB6 impacts mitochondrial function and porphyrin transport, contributing to metabolic disorders and emphasizing its importance in maintaining cellular and systemic homeostasis.

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