Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) Protein

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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein ABCB6
proveedor
Abbexareference
abx650380Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human ABCB6 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ABCB6 is a mitochondrial ATP-binding cassette transporter critical for the transport of porphyrins and precursors involved in heme biosynthesis. Localized to the outer mitochondrial membrane, ABCB6 facilitates the uptake of coproporphyrinogen III, a precursor in the heme biosynthesis pathway, enabling its conversion to protoporphyrin IX within mitochondria. ABCB6 is highly expressed in erythroid cells, liver, and other tissues with high heme demands, supporting processes such as oxygen transport and detoxification. In addition to its role in heme production, ABCB6 is involved in the cellular response to oxidative stress and drug metabolism. Mutations in ABCB6 have been associated with disorders like familial pseudohyperkalemia and dyschromatosis universalis hereditaria, affecting red blood cells and pigmentation, respectively. Dysregulation of ABCB6 impacts mitochondrial function and porphyrin transport, contributing to metabolic disorders and emphasizing its importance in maintaining cellular and systemic homeostasis.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
ATP-Binding Cassette Sub-Family B Member 6 (ABCB6)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 31.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile590-Arg842 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCB6
dry ice
No
availability
Shipped within 5-7 working days.
alias
LAN,MTABC3
uniprot id
NCBI accession
NP_005680.1, NM_005689.2
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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