Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) Protein

Este producto es parte de ABCB - ATP binding cassette subfamily B member
Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein ABCB6

proveedor

Abbexa

reference

abx650380

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ABCB6 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ABCB6 is a mitochondrial ATP-binding cassette transporter critical for the transport of porphyrins and precursors involved in heme biosynthesis. Localized to the outer mitochondrial membrane, ABCB6 facilitates the uptake of coproporphyrinogen III, a precursor in the heme biosynthesis pathway, enabling its conversion to protoporphyrin IX within mitochondria. ABCB6 is highly expressed in erythroid cells, liver, and other tissues with high heme demands, supporting processes such as oxygen transport and detoxification. In addition to its role in heme production, ABCB6 is involved in the cellular response to oxidative stress and drug metabolism. Mutations in ABCB6 have been associated with disorders like familial pseudohyperkalemia and dyschromatosis universalis hereditaria, affecting red blood cells and pigmentation, respectively. Dysregulation of ABCB6 impacts mitochondrial function and porphyrin transport, contributing to metabolic disorders and emphasizing its importance in maintaining cellular and systemic homeostasis.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

ATP-Binding Cassette Sub-Family B Member 6 (ABCB6)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 31.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile590-Arg842 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCB6


dry ice

No


availability

Shipped within 5-7 working days.


alias

LAN,MTABC3


NCBI accession

NP_005680.1, NM_005689.2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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