Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) ELISA Kit

Este producto es parte de ABCB - ATP binding cassette subfamily B member
Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for ABCB6

proveedor

Abbexa

reference

abx385541

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

ABCB6 is a mitochondrial ATP-binding cassette transporter critical for the transport of porphyrins and precursors involved in heme biosynthesis. Localized to the outer mitochondrial membrane, ABCB6 facilitates the uptake of coproporphyrinogen III, a precursor in the heme biosynthesis pathway, enabling its conversion to protoporphyrin IX within mitochondria. ABCB6 is highly expressed in erythroid cells, liver, and other tissues with high heme demands, supporting processes such as oxygen transport and detoxification. In addition to its role in heme production, ABCB6 is involved in the cellular response to oxidative stress and drug metabolism. Mutations in ABCB6 have been associated with disorders like familial pseudohyperkalemia and dyschromatosis universalis hereditaria, affecting red blood cells and pigmentation, respectively. Dysregulation of ABCB6 impacts mitochondrial function and porphyrin transport, contributing to metabolic disorders and emphasizing its importance in maintaining cellular and systemic homeostasis.

Características del producto

category

ELISA Kits


immunogen target

ATP-Binding Cassette Sub-Family B Member 6 (ABCB6)


reactivity

Human


test range

0.312 ng/ml - 20 ng/ml


sensitivity

< 0.2 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

LAN,MTABC3


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

ABCB6


dry ice

No


NCBI accession

NP_005680.1, NM_005689.2


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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