Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ABCB6
proveedor
Abbexareference
abx385541Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ATP-Binding Cassette Sub-Family B Member 6 (ABCB6) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ABCB6 is a mitochondrial ATP-binding cassette transporter critical for the transport of porphyrins and precursors involved in heme biosynthesis. Localized to the outer mitochondrial membrane, ABCB6 facilitates the uptake of coproporphyrinogen III, a precursor in the heme biosynthesis pathway, enabling its conversion to protoporphyrin IX within mitochondria. ABCB6 is highly expressed in erythroid cells, liver, and other tissues with high heme demands, supporting processes such as oxygen transport and detoxification. In addition to its role in heme production, ABCB6 is involved in the cellular response to oxidative stress and drug metabolism. Mutations in ABCB6 have been associated with disorders like familial pseudohyperkalemia and dyschromatosis universalis hereditaria, affecting red blood cells and pigmentation, respectively. Dysregulation of ABCB6 impacts mitochondrial function and porphyrin transport, contributing to metabolic disorders and emphasizing its importance in maintaining cellular and systemic homeostasis.
Características del producto
category
ELISA Kits
immunogen target
ATP-Binding Cassette Sub-Family B Member 6 (ABCB6)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.2 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
LAN,MTABC3
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ABCB6
dry ice
No
uniprot id
NCBI accession
NP_005680.1, NM_005689.2
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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