Human Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) ELISA Kit

Este producto es parte de ALOX - Arachidonate lipoxygenase
Human Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for ALOX5AP

proveedor

Abbexa

reference

abx384597

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP) is a crucial regulatory protein that facilitates the activity of 5-lipoxygenase (5-LOX), an enzyme involved in the biosynthesis of leukotrienes. Leukotrienes are lipid mediators derived from arachidonic acid that play significant roles in inflammatory and allergic responses, including bronchoconstriction, vascular permeability, and recruitment of immune cells. ALOX5AP acts as an essential cofactor, enabling 5-LOX to translocate to the nuclear membrane and interact with its substrate, leading to the production of leukotrienes. Dysregulation of ALOX5AP has been implicated in various inflammatory diseases, including asthma, atherosclerosis, and rheumatoid arthritis. Genetic variants in the ALOX5AP gene are associated with an increased risk of cardiovascular disease and stroke, making it a potential biomarker and therapeutic target. Inhibitors targeting ALOX5AP or its interaction with 5-LOX are being explored as treatments to mitigate leukotriene-mediated inflammatory conditions.

Características del producto

category

ELISA Kits


immunogen target

Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.05 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

ALOX5AP,FLAP


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

ALOX5AP


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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