Human Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Protein
208€ (10 µg)
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935106861
info@markelab.com
name
Human Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650287
tested applications
WB, SDS-PAGE
Description
Human ALOX12B Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 29.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu479-Ile701 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75342 |
| Alias | 12R-LOX,12R-lipoxygenase,Epidermis-type lipoxygenase 12,arachidonate lipoxygenase 3 |
| Background | Protein ALOX12B |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ALOX12B is a lipoxygenase enzyme that specifically oxygenates arachidonic acid to form 12(R)-hydroperoxyeicosatetraenoic acid [12(R)-HPETE], which is further metabolized to 12(R)-HETE. ALOX12B is primarily expressed in the epidermis, where it plays a critical role in skin barrier formation and maintenance. It is involved in the biosynthesis of specialized lipids required for the development of the cornified lipid envelope, a structure essential for skin permeability and protection. Mutations in ALOX12B are linked to autosomal recessive congenital ichthyosis (ARCI), a skin disorder characterized by scaling, dryness, and impaired barrier function due to defective lipid metabolism. Beyond its role in skin biology, ALOX12B has been implicated in inflammation and wound healing processes. Dysregulation of ALOX12B may contribute to skin-related disorders and inflammatory skin diseases, making it an important target for understanding epidermal homeostasis and barrier repair therapies.
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