Human Apoptosis-Inducing Factor 3 (AIFM3) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Apoptosis-Inducing Factor 3 (AIFM3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385672
tested applications
ELISA
Description
Human Apoptosis-Inducing Factor 3 (AIFM3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Apoptosis Inducing Factor, Mitochondrion Associated 3 (AIFM3) concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Apoptosis-Inducing Factor 3 (AIFM3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.15 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96NN9 |
| Gene ID | 150209 |
| OMIM | 617298 |
| Alias | AIFM3, AIFL |
| Background | Elisa kits for AIFM3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Apoptosis Inducing Factor Mitochondria Associated 3 (AIFM3) is a mitochondrial protein belonging to the apoptosis-inducing factor family, which is involved in regulating programmed cell death and maintaining cellular homeostasis. Unlike AIFM1, which translocates to the nucleus during apoptosis to induce DNA fragmentation, AIFM3 is primarily localized within the mitochondria and functions to maintain mitochondrial integrity and energy metabolism. It plays a role in redox homeostasis and may act as a safeguard against oxidative stress by modulating mitochondrial reactive oxygen species (ROS) production. Dysregulation of AIFM3 has been implicated in cancer, where altered apoptotic signaling contributes to tumor survival and chemoresistance. Emerging studies suggest that AIFM3 may also participate in non-apoptotic pathways, such as cellular differentiation and response to metabolic stress, making it a potential target for therapeutic intervention in mitochondrial dysfunction-related diseases and cancer.
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