Apoptosis-Inducing Factor 3 (AIFM3) Antibody

Este producto es parte de AIFM - Apoptosis inducing factor mitochondria associated
Apoptosis-Inducing Factor 3 (AIFM3) Antibody

Pida mas información

935106861

info@markelab.com

Precio

637€ (100 µl)

Antibody anti-AIFM3

proveedor

Abbexa

reference

abx111034

Tested Applications

ELISA, WB, IHC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

Apoptosis-Inducing Factor, Mitochondrion-Associated, 3 Antibody is a Rabbit Polyclonal antibody against Apoptosis-Inducing Factor, Mitochondrion-Associated, 3.


Background

Apoptosis Inducing Factor Mitochondria Associated 3 (AIFM3) is a mitochondrial protein belonging to the apoptosis-inducing factor family, which is involved in regulating programmed cell death and maintaining cellular homeostasis. Unlike AIFM1, which translocates to the nucleus during apoptosis to induce DNA fragmentation, AIFM3 is primarily localized within the mitochondria and functions to maintain mitochondrial integrity and energy metabolism. It plays a role in redox homeostasis and may act as a safeguard against oxidative stress by modulating mitochondrial reactive oxygen species (ROS) production. Dysregulation of AIFM3 has been implicated in cancer, where altered apoptotic signaling contributes to tumor survival and chemoresistance. Emerging studies suggest that AIFM3 may also participate in non-apoptotic pathways, such as cellular differentiation and response to metabolic stress, making it a potential target for therapeutic intervention in mitochondrial dysfunction-related diseases and cancer.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

Apoptosis-Inducing Factor 3 (AIFM3)


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC


purification

Antigen Affinity Chromatography.


recommended dilution

Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol.


size 1

100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

AIFM3


dry ice

No


availability

Shipped within 5-10 working days.


alias

AIFM3, AIFL


NCBI accession

NP_001018070.1, NM_001018060.2, NP_001139760.1, NM_001146288.1, NP_653305.1, NM_144704.2


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