Human Apoptosis-inducing factor 2 (AIFM2) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Apoptosis-inducing factor 2 (AIFM2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501336
tested applications
ELISA
Description
Human Apoptosis-inducing factor 2 (AIFM2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Apoptosis-inducing factor 2 (AIFM2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Apoptosis-inducing factor 2 (AIFM2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9BRQ8 |
| Alias | AIFM2,AMID,PRG3 |
| Background | Elisa kits for AIFM2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AIFM2, also known as AMID (apoptosis-inducing factor-homologous mitochondrion-associated inducer of death), is a flavoprotein localized in the cytosol and mitochondria, where it participates in redox signaling and apoptosis regulation. Unlike AIFM1, AIFM2 induces apoptosis through reactive oxygen species (ROS)-mediated mechanisms rather than direct DNA fragmentation. It plays a role in the cellular response to oxidative stress, linking mitochondrial dysfunction to apoptotic pathways. AIFM2 is also associated with metabolic regulation and has been reported to modulate the cellular response to hypoxia. Dysregulation of AIFM2 expression has been linked to cancer progression, with evidence suggesting its tumor suppressor function in certain contexts. The interplay between AIFM2 and oxidative stress pathways makes it a critical component of cellular homeostasis, particularly under stress conditions that compromise mitochondrial function.
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