Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx125507
tested applications
WB, IHC
Description
AIFM2 Antibody is a Rabbit Polyclonal against AIFM2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apoptosis Inducing Factor, Mitochondria Associated 2 (AIFM2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BRQ8 |
| Gene ID | 84883 |
| NCBI Accession | NP_116186.1 |
| Alias | AIFM2,AMID,PRG3 |
| Background | Antibody anti-AIFM2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AIFM2, also known as AMID (apoptosis-inducing factor-homologous mitochondrion-associated inducer of death), is a flavoprotein localized in the cytosol and mitochondria, where it participates in redox signaling and apoptosis regulation. Unlike AIFM1, AIFM2 induces apoptosis through reactive oxygen species (ROS)-mediated mechanisms rather than direct DNA fragmentation. It plays a role in the cellular response to oxidative stress, linking mitochondrial dysfunction to apoptotic pathways. AIFM2 is also associated with metabolic regulation and has been reported to modulate the cellular response to hypoxia. Dysregulation of AIFM2 expression has been linked to cancer progression, with evidence suggesting its tumor suppressor function in certain contexts. The interplay between AIFM2 and oxidative stress pathways makes it a critical component of cellular homeostasis, particularly under stress conditions that compromise mitochondrial function.
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