Human Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) ELISA Kit
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Description
Human Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Apoptosis Inducing Factor concentrations in serum, plasma and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.25 pg/ml - 2000 pg/ml |
| Sensitivity | 18.75 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | AIFM1,AIF,CMT2D,CMTX4,COWCK |
| Background | Elisa kits for AIFM1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AIFM1 is a key mitochondrial protein that mediates caspase-independent apoptosis while also playing essential roles in mitochondrial energy metabolism. Located in the mitochondrial intermembrane space, AIFM1 translocates to the nucleus in response to apoptotic stimuli, where it induces chromatin condensation and large-scale DNA fragmentation. This translocation is triggered by mitochondrial outer membrane permeabilization during cellular stress. Beyond its apoptotic function, AIFM1 is crucial for maintaining mitochondrial respiratory chain integrity and supporting cellular energy homeostasis. Mutations in the AIFM1 gene have been implicated in neurodegenerative disorders and mitochondrial encephalomyopathies, highlighting its dual role in apoptosis and bioenergetics. Its regulation and activity are critical for cellular fate, as dysregulation can lead to either excessive apoptosis, contributing to degenerative diseases, or impaired apoptosis, facilitating cancer progression.
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This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
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