Human Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) ELISA Kit
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935106861
info@markelab.com
Precio
689€ (96 tests)
Elisa kits for AIFM1
proveedor
Abbexareference
abx150599Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Apoptosis Inducing Factor (AIF) concentrations in serum, plasma, tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Apoptosis Inducing Factor (AIF)
Background
AIFM1 is a key mitochondrial protein that mediates caspase-independent apoptosis while also playing essential roles in mitochondrial energy metabolism. Located in the mitochondrial intermembrane space, AIFM1 translocates to the nucleus in response to apoptotic stimuli, where it induces chromatin condensation and large-scale DNA fragmentation. This translocation is triggered by mitochondrial outer membrane permeabilization during cellular stress. Beyond its apoptotic function, AIFM1 is crucial for maintaining mitochondrial respiratory chain integrity and supporting cellular energy homeostasis. Mutations in the AIFM1 gene have been implicated in neurodegenerative disorders and mitochondrial encephalomyopathies, highlighting its dual role in apoptosis and bioenergetics. Its regulation and activity are critical for cellular fate, as dysregulation can lead to either excessive apoptosis, contributing to degenerative diseases, or impaired apoptosis, facilitating cancer progression.
Características del producto
category
ELISA Kits
immunogen target
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1)
reactivity
Human
test range
15.6 pg/ml - 1000 pg/ml
sensitivity
< 5.5 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
AIFM1,AIF,CMT2D,CMTX4,COWCK
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
AIFM1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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