Human Apolipoprotein M (APOM) Protein

Este producto es parte de APOM - Apolipoprotein M
Human Apolipoprotein M (APOM) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein APOM

proveedor

Abbexa

reference

abx065437

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Apolipoprotein M (APOM) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Apolipoprotein M (APOM) is a member of the apolipoprotein family primarily involved in lipid transport and metabolism. APOM is predominantly expressed in the liver and kidneys and is secreted into the plasma, where it associates mainly with high-density lipoprotein (HDL) particles. APOM plays a key role in lipid homeostasis by transporting sphingosine-1-phosphate (S1P), a bioactive lipid mediator involved in immune response, vascular development, and endothelial barrier integrity. APOM also enhances the anti-inflammatory and antioxidant properties of HDL, contributing to its atheroprotective function in cardiovascular health. Recent studies suggest that APOM regulates the S1P signaling pathway, which is crucial for lymphocyte trafficking, vascular permeability, and cell survival. Altered APOM levels have been observed in metabolic disorders such as type 2 diabetes, atherosclerosis, and cardiovascular disease, highlighting its role as a biomarker and potential therapeutic target. Its involvement in the modulation of endothelial function, cholesterol efflux, and immune regulation underscores APOM's critical role in maintaining cardiovascular and metabolic homeostasis. Ongoing research aims to explore APOM’s therapeutic potential, particularly in improving HDL functionality and S1P-based signaling for cardiovascular disease prevention.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Apolipoprotein M (APOM)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 27.0 kDa Observed MW (SDS-PAGE): 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala8-Asn188 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

APOM


dry ice

No


availability

Shipped within 5-7 working days.


alias

APOM, G3a, HSPC336, NG20, apo-M, apolipoprotein M


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


Quizá le pueda interesar

Human APOM(Apolipoprotein M) ELISA Kit

Human APOM(Apolipoprotein M) ELISA Kit

proveedor

FineTest

reference

EH2134

reactivity

human

status

RUO

Precio a consultar

Ver más

Porcine ApoM(Apolipoprotein M) ELISA Kit

Porcine ApoM(Apolipoprotein M) ELISA Kit

proveedor

FineTest

reference

EP0019

reactivity

porcine

status

RUO

Precio a consultar

Ver más

anti- APOM antibody

anti- APOM antibody

proveedor

FineTest

reference

FNab00511

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, r...

Precio a consultar

Ver más