Apolipoprotein M (ApoM) Antibody

Este producto es parte de APOM - Apolipoprotein M
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383.5€ (100 µl)

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935106861
info@markelab.com
name
Apolipoprotein M (ApoM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx010417
tested applications
ELISA, WB, IF/ICC

Description

ApoM (apolipoprotein M, also designated G3a or NG20), with 188-amino acid protein (about 21kDa), is an apolipoprotein and member of the lipocalin protein family. The Apo-proteins are involved in the specific binding of cellular receptors, the regulation of lipolytic enzymes, and the process of lipid exchange. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. The N-terminal region of Apo-M contains hydrophobic residues that may promote association with the phospholipid layer of lipoprotein particles.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Apolipoprotein M (ApoM)
Host
Mouse
Reactivity
Human
Recommended Dilution
ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purification
Unpurified ascites.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, WB, IF/ICC
Buffer
Ascitic fluid containing 0.03% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O95445
Gene ID
55937
OMIM
606907
Alias
APOM, G3a, HSPC336, NG20, apo-M, apolipoprotein M
Background
Antibody anti-APOM
Status
RUO
Note
Concentration: Not determined. -

Descripción

Apolipoprotein M (APOM) is a member of the apolipoprotein family primarily involved in lipid transport and metabolism. APOM is predominantly expressed in the liver and kidneys and is secreted into the plasma, where it associates mainly with high-density lipoprotein (HDL) particles. APOM plays a key role in lipid homeostasis by transporting sphingosine-1-phosphate (S1P), a bioactive lipid mediator involved in immune response, vascular development, and endothelial barrier integrity. APOM also enhances the anti-inflammatory and antioxidant properties of HDL, contributing to its atheroprotective function in cardiovascular health. Recent studies suggest that APOM regulates the S1P signaling pathway, which is crucial for lymphocyte trafficking, vascular permeability, and cell survival. Altered APOM levels have been observed in metabolic disorders such as type 2 diabetes, atherosclerosis, and cardiovascular disease, highlighting its role as a biomarker and potential therapeutic target. Its involvement in the modulation of endothelial function, cholesterol efflux, and immune regulation underscores APOM's critical role in maintaining cardiovascular and metabolic homeostasis. Ongoing research aims to explore APOM’s therapeutic potential, particularly in improving HDL functionality and S1P-based signaling for cardiovascular disease prevention.

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