Human Apolipoprotein B-100 (APOB) Protein
1339€ (1 mg)
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name
Human Apolipoprotein B-100 (APOB) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652314
tested applications
WB, SDS-PAGE
Description
Human Apolipoprotein B-100 (APOB) Protein is a Native Human protein expressed in Human.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Apolipoprotein B-100 (APOB) |
| Host | Human |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 515.6 kDa Concentration: Prior to lyophilization: 200 µg/ml |
| Expression | Native |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04114 |
| Alias | APOB, FLDB, LDLCQ4, apoB-100,apolipoprotein B, FCHL2 |
| Background | Protein APOB |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
APOB is a major structural protein of low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL), and chylomicrons, which are essential for lipid transport and metabolism in the body It exists in two primary isoforms: APOB-100, produced in the liver, and APOB-48, synthesized in the intestine APOB-100 is critical for the assembly and secretion of VLDL and LDL particles, facilitating the transport of cholesterol and triglycerides to peripheral tissues via binding to the LDL receptor (LDLR) Mutations or overexpression of APOB contribute to familial hypercholesterolemia and other dyslipidemias, leading to elevated LDL cholesterol levels and increased risk of atherosclerosis and cardiovascular diseases APOB-48, on the other hand, plays a key role in chylomicron formation and dietary fat absorption Genetic variations in the APOB gene have been linked to metabolic disorders, including obesity, diabetes, and fatty liver disease APOB levels serve as a marker of cardiovascular risk, with elevated concentrations indicating higher susceptibility to coronary artery disease Therapies targeting APOB, such as antisense oligonucleotides or LDL-lowering drugs like statins, have shown significant success in reducing cardiovascular events APOB remains a key focus in lipid biology due to its central role in lipid transport and cardiovascular health
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