Recombinant Apelin (APLN) is a recombinant Human protein produced in E. coli using Prokaryotic expression.
Apelin, also known as APLN, is a peptide encoded by the APLN gene in humans. It serves as one of two endogenous ligands for the G-protein-coupled APJ receptor, which is expressed on the surface of many cell types. The Apelin gene encodes a pre-proprotein consisting of 77 amino acids, with a signal peptide at the N-terminal region. Translocation into the endoplasmic reticulum and cleavage of the signal peptide, the resulting protein, made up of 55 amino acids, can generate multiple active fragments. Apelin 36: A 36 amino acid peptide corresponding to the sequence 42-77. Apelin 17: A 17 amino acid peptide corresponding to the sequence 61-77. Apelin 13: A 13 amino acid peptide corresponding to the sequence 65-77. Ap-12, one of the most potent C-terminal fragments of this polypeptide, exhibits a high affinity for the orphan receptor APJ. Apelin-12 is involved in regulating body fluid homeostasis and plays a role in central control of feeding. Interestingly, Apelin-12 also has the ability to block HIV-1. Other aliases for apelin include APEL, XNPEP2, and apelin.
Proteins and Peptides
Human
E. coli
Apelin (APLN)
E. coli
Unconjugated
Lyophilized
WB, SDS-PAGE
10 µg
50 µg
100 µg
200 µg
1 mg
Recombinant
> 95%
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
APLN
No
Shipped within 5-7 working days.
APLN,APJ endogenous ligand,
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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