[Tyr0]-Apelin-13 is a peptide.
Apelin, also known as APLN, is a peptide encoded by the APLN gene in humans. It serves as one of two endogenous ligands for the G-protein-coupled APJ receptor, which is expressed on the surface of many cell types. The Apelin gene encodes a pre-proprotein consisting of 77 amino acids, with a signal peptide at the N-terminal region. Translocation into the endoplasmic reticulum and cleavage of the signal peptide, the resulting protein, made up of 55 amino acids, can generate multiple active fragments. Apelin 36: A 36 amino acid peptide corresponding to the sequence 42-77. Apelin 17: A 17 amino acid peptide corresponding to the sequence 61-77. Apelin 13: A 13 amino acid peptide corresponding to the sequence 65-77. Ap-12, one of the most potent C-terminal fragments of this polypeptide, exhibits a high affinity for the orphan receptor APJ. Apelin-12 is involved in regulating body fluid homeostasis and plays a role in central control of feeding. Interestingly, Apelin-12 also has the ability to block HIV-1. Other aliases for apelin include APEL, XNPEP2, and apelin.
Proteins and Peptides
Human, Cow, Mouse, Rat
[Tyr0]-Apelin-13
Unconjugated
5 mg
10 mg
25 mg
Not applicable.
Store dry at -20 °C. Avoid repeated freeze/thaw cycles.
AP13
No
Shipped within 10-20 working days.
AP13,APLN
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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