Human Antithrombin-III (SERPINC1) Protein
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Description
Human Antithrombin-III (SERPINC1) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 50.93 kDa Observed MW (SDS-PAGE): 60 kDa Sequence Fragment: Met1-Lys464 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | P01008 |
| Alias | AT3,AT3D,ATIII,THPH7,ATIII-R2,ATIII-T1,ATIII-T2,Antithrombin-III,Serpin C1 |
| Background | Protein SERPINC1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SERPINC1, commonly known as the gene encoding antithrombin (AT), is a critical member of the serine protease inhibitor (serpin) family. Antithrombin is primarily synthesized in the liver and secreted into the bloodstream, where it plays a vital role in regulating blood coagulation. As a serpin, its primary function is to inhibit proteases involved in coagulation, such as thrombin and factor Xa, thereby preventing excessive clot formation. Deficiencies or abnormalities in the SERPINC1 gene are closely associated with thrombotic disorders, as they lead to an increased risk of blood clots due to insufficient antithrombin activity. This deficiency can be inherited or acquired, and it plays a significant role in conditions such as deep vein thrombosis (DVT) and pulmonary embolism (PE).
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SERPINC1 Antibody is a Rabbit Polyclonal antibody against SERPINC1. SERPINC1, also named Antithrombin III or Antithrombin, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
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The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. This antibody is supplied as crude ascites.
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