Antithrombin-III (SERPINC1) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Antithrombin-III (SERPINC1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025423
tested applications
ELISA, WB
Description
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Antithrombin-III (SERPINC1) |
| Host | Mouse |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified Mouse Monoclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01008 |
| Alias | AT3,AT3D,ATIII,THPH7,ATIII-R2,ATIII-T1,ATIII-T2,Antithrombin-III,Serpin C1 |
| Background | Antibody anti-SERPINC1 |
| Status | RUO |
Descripción
SERPINC1, commonly known as the gene encoding antithrombin (AT), is a critical member of the serine protease inhibitor (serpin) family. Antithrombin is primarily synthesized in the liver and secreted into the bloodstream, where it plays a vital role in regulating blood coagulation. As a serpin, its primary function is to inhibit proteases involved in coagulation, such as thrombin and factor Xa, thereby preventing excessive clot formation. Deficiencies or abnormalities in the SERPINC1 gene are closely associated with thrombotic disorders, as they lead to an increased risk of blood clots due to insufficient antithrombin activity. This deficiency can be inherited or acquired, and it plays a significant role in conditions such as deep vein thrombosis (DVT) and pulmonary embolism (PE).
Related Products
Human Antithrombin-III (SERPINC1) ELISA Kit
Human Antithrombin-III (SERPINC1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Thrombin concentrations in serum, plasma, cell culture supernatants, tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Thrombin
Ver Producto
Antithrombin-III (SERPINC1) Antibody (FITC)
SERPINC1 Antibody (FITC) is a Rabbit Polyclonal against SERPINC1 conjugated to FITC.
Ver Producto