Human Anti-Protein Tyrosine Phosphatase-Like N IgG (PTPRN IgG) ELISA Kit
513.5€ (96 tests)
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935106861
info@markelab.com
name
Human Anti-Protein Tyrosine Phosphatase-Like N IgG (PTPRN IgG) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx364949
tested applications
ELISA
Description
Tyrosine Phosphatase IA-2 (TP-IA-2) IgG ELISA Kit is an ELISA Kit against Tyrosine Phosphatase IA-2 (TP-IA-2) IgG.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Anti-Protein Tyrosine Phosphatase-Like N IgG (PTPRN IgG) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Qualitative |
| Assay Type | Indirect |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IA2,IA-2,ICA512,R-PTP-N,IA-2/PTP,Islet cell autoantigen 3,PTP IA-2,Islet cell antigen 512,R-PTP-N,Receptor-type tyrosine-protein phosphatase-like N |
| Background | Elisa kits for PTPRN |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PTPRN, also known as IA-2, is a receptor-like protein tyrosine phosphatase predominantly expressed in neuroendocrine tissues, particularly in pancreatic β-cells. Structurally, it features a single transmembrane domain and an intracellular region that lacks phosphatase activity due to critical residue substitutions. PTPRN functions as a key regulator of insulin secretion and is essential for the formation and stability of secretory granules in endocrine cells. It interacts with granule components to facilitate the docking and exocytosis of insulin and other hormones. PTPRN is also an autoantigen in type 1 diabetes mellitus (T1DM), where autoimmune responses against it lead to β-cell destruction. Its role in neuroendocrine cell function emphasizes its importance in glucose homeostasis and diabetes pathogenesis. Mutations or dysregulation of PTPRN have been implicated in metabolic disorders and neurodegenerative diseases.
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