Human Anti-KLHL12 (anti-Kelch-like protein 12 antibody) ELISA Kit

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Product specifications
Category | ELISA Kits |
Reactivity | Human |
Assay Data | 3 hours |
Assay Type | HRP Indirect ELISA Sandwich |
Test Range | 1.563-100ng/ml |
Sensitivity | 0.938ng/ml |
Size 1 | 96T |
Tested Applications | ELISA |
Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
Availability | Shipped within 10-14 working days. |
Storage | 2-8 °C for 12 months |
UniProt ID | Q53G59 |
Alias | Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog, hDKIR, KLHL12, C3IP1 |
Background | Elisa kits for KLHL12 |
Status | RUO |
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KLHL12 antibody
Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem(ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31(SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
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